TAK-243 preferentially sure to UBA1 in excess of the associated E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 lowered levels of ubiquitylated proteins, increased markers of proteotoxic strain and DNA problems stress. In vivo, TAK-243 minimized leukemic stress and targeted leukemic stem cells https://emilyd332vkx8.law-wiki.com/user