TAK-243 preferentially sure to UBA1 above the connected E1 enzymes UBA2, UBA3, and UBA6 in intact AML cells. Inhibition of UBA1 with TAK-243 diminished levels of ubiquitylated proteins, greater markers of proteotoxic tension and DNA problems anxiety. In vivo, TAK-243 reduced leukemic load and qualified leukemic stem cells without evidence https://dickw853nrv6.life3dblog.com/profile